Introduction
Building a cross-disciplinary scientific community and supporting visionary, early-stage research.
About
The Chan Zuckerberg Biohub Chicago has funded its first cohort of Investigators at its partner institutions, Northwestern University, the University of Chicago, and the University of Illinois Urbana-Champaign. This funding will enable Investigators to perform high-risk, high-reward research on topics related to instrumented tissues and research linked to inflammation and the functions of the immune system.
Single and Team proposals were selected after a competitive process that led to 25 projects and 48 investigators. Investigators will attend Quarterly Investigator Meetings, which provide opportunities to build collaborative efforts between partner universities and Biohub scientists and engineers, present progress from ongoing work, and interact with external speakers.
Funded Projects
An instrumented humanized neuroinflammation-on-chip: function and inflammation
- Bumsoo Han, Ph.D., University of Illinois Urbana-Champaign
- Martha Gillette, Ph.D., University of Illinois Urbana-Champaign
Assessing and treating inflammatory drivers of cardiac arrhythmias and heart failure using human heart organoids
- Elizabeth McNally, M.D, Ph.D., Northwestern University
- Igor Efimov, Ph.D., Northwestern University
- Dominic Fullenkamp, M.D., Ph.D., Northwestern University
Cellular contractility and mechanotransduction in the neuroinflammatory response
- M Taher Saif, Ph.D., University of Illinois Urbana-Champaign
- Hyunjoon Kong, Ph.D., University of Illinois Urbana-Champaign
- Qian Chen, Ph.D., University of Illinois Urbana-Champaign
Data-driven pipelines to learn and engineer spatiotemporal patterning in endothelial inflammation
- Margaret Gardel, Ph.D., University of Chicago
- Vincenzo Vitelli, Ph.D., University of Chicago
Elucidating metabolic drivers of foamy macrophage reprogramming in diverse environments
- Lisa Volpatti, Ph.D., Northwestern University
Engineered probiotics as living medicine for inflammatory disease
- Shannon J. Sirk, Ph.D., University of Illinois Urbana-Champaign
- Arthur Prindle, Ph.D., Northwestern University
Enhancing understanding of the biology of inflammation: the immuno-metabolic axis
- Navdeep S. Chandel, Ph.D., Northwestern University
Expanding analytical methodologies to address challenges in cytokine analysis
- Mei Shen, Ph.D., University of Illinois Urbana-Champaign
Hydrogel-based, immune-compatible 3D bioelectronics for evolvable biotic-abiotic interfaces
- Sihong Wang, Ph.D., University of Chicago
Large-scale application of protein language models to TCR-peptide interactions
- Aly A. Khan, Ph.D., University of Chicago
Live cell analysis device (LCAD) with multiplexed cytokine sensing for investigation of neuroinflammatory phenotypes
- Horacio Espinosa, Ph.D., Northwestern University
- John Kessler, M.D., Northwestern University
- Chian-Yu Peng, Ph.D., Northwestern University
Mapping dynamic RNA-protein interactions in inflammation: from cells to animals to patients
- Bryan Dickinson, Ph.D., University of Chicago
- Benjamin Shogan, M.D., University of Chicago
mRNA biogenesis kinetics in inflammation
- Luis Barreiro, Ph.D., University of Chicago
- Yang Li, Ph.D., University of Chicago
Multimodal imaging technologies for recording the immune landscape in tissues
- Catherine Murphy, Ph.D. , University of Illinois Urbana-Champaign
- Rohit Bhargava, Ph.D., University of Illinois Urbana-Champaign
Multiscale deconstruction of inflammation and reprogramming in human livers
- Auinash Kalsotra, Ph.D., University of Illinois Urbana-Champaign
- Yogesh Goyal, Ph.D., Northwestern University
Nano-electrophoresis for enhanced detection of inflammatory and immune protein signaling
- Yurii Vlasov, Ph.D., University of Illinois Urbana-Champaign
Probing spatiotemporal dynamics of tumor immunity with a high-throughput model system
- Melody Swartz, Ph.D., University of Chicago
Quantitative, spatial-temporal imaging in female reproductive tissues
- Amy Wagoner Johnson, Ph.D., University of Illinois Urbana-Champaign
- Indrani Bagchi, Ph.D., University of Illinois Urbana-Champaign
- Bradley Sutton, Ph.D., University of Illinois Urbana-Champaign
- Ayelet Ziv-Gal, Ph.D., University of Illinois Urbana-Champaign
Quantum ID for measuring millions of immune cells simultaneously
- Aaron Esser-Kahn, Ph.D., University of Chicago
- Peter Maurer, Ph.D., University of Chicago
- Alexander T. Pearson, M.D., Ph.D., University of Chicago
Single-cell metabolomics and proteomics of inflamed and engineered human skin
- Neil Kelleher, Ph.D., Northwestern University
- Jonathan Sweedler, Ph.D., University of Illinois Urbana-Champaign
Single-molecule immunoassay for detection of inflammation in instrumented tissue
- Allison Squires, Ph.D., University of Chicago
- Samantha Riesenfeld, Ph.D., University of Chicago
Spatially resolved proteomic characterization and computational modeling of lymphoid tissues in 3D
- Savas Tay, Ph.D., University of Chicago
- Marcus Clark, M.D., Ph.D., University of Chicago
Spatiotemporal analyses of the human tumor-immune interactome
- Huiping Liu, M.D., Ph.D., Northwestern University
- Lee Cooper, Ph.D., Northwestern University
Targeting technologies for the delivery of biologically relevant payloads to pathogenic T cells
- Jaehyuk Choi, M.D., Ph.D., Northwestern University
Uncovering signal-specific inflammatory responses in 3D tumor microenvironments utilizing SNA nanoprobes
- Chad Mirkin, Ph.D., Northwestern University
- Ali Shilatifard, Ph.D., Northwestern University
Program Staff
Shana O. Kelley, Ph.D.
President, CZ Biohub Chicago
Gene Robinson, Ph.D.
Director, Extramural Programs
Basia Galinski, Ph.D.
Programs Manager
CONTACT US
For information and inquiries, email: awards@chicago.czbiohub.org.
