Antibodies attacking neurons in autoimmune neurologic diseases
Our Research
Harnessing the power of functional genomics to revolutionize our understanding of immune system behavior and its implications for therapy.
Located in the CZ Biohub Chicago, the Functional Immunogenomics Group is dedicated to uncovering the complex mechanisms of immune cell function and interaction. By integrating cutting-edge technologies and multi-omics approaches, we aim to fast-track discoveries in cellular communication, cytokine secretion, and immune cell homing. Our research is driving forward the development of next-generation therapeutics.
Research Focus
Immune cells locating cancer cells
- Systematic Gene Perturbation
- Goal: Identify key mediators of inflammation and dysfunction by perturbing genes in immune cells within disease-relevant models.
- Approach: Use precise CRISPR technologies (Knockout, Activation, Base-editing) to edit genes and analyze the effects on immune response, paving the way for potential therapeutic targets.
- AI Integration
- Goal: Leverage artificial intelligence to decode complex biological datasets, revealing patterns and predicting gene functions with unprecedented precision.
- Techniques: Implement advanced machine learning algorithms to enhance our analysis and interpretation of vast genomic datasets.
- Deeper Insights
- Goal: Advance our understanding of inflammatory pathways to develop innovative strategies for disease management and tracking.
- Method: Employ state-of-the-art analytical and engineering techniques to delve deeper into the regulatory mechanisms of the immune system.
- Strategic Collaborations
- Goal: Amplify our capabilities and accelerate disruptive discoveries through national and global partnerships.
- Network: Collaborate with leading academic institutions, tech companies, and biopharmaceutical leaders to push the boundaries of what is possible in functional genomics.
Vision for the Future
Our group is at the forefront of developing novel strategies and technologies that enhance our fundamental understanding of immunology and set the stage for significant breakthroughs in therapeutic applications. With a deep commitment to innovation and excellence, we are paving the way towards more effective treatments for inflammatory diseases and beyond.
