Mapping dynamic cell systems

Intracellular Architecture

Bringing together cell biologists, data scientists, and engineers, the team led by Manuel Leonetti is building reference maps of how the human cell is internally organized. Their flagship project, OpenCell, characterizes the spatial locations and molecular interactions of the proteins that make up the cell.

Organismal Architecture

​​A pluridisciplinary team of computer scientists, optical engineers, and biologists, Loïc Royer and his team are building Zebrahub, a time-resolved, multidimensional atlas of vertebrate development using zebrafish as a model organism.

Organismal Infection Biology

Keir Balla‘s group discovers zebrafish viruses and deploys them as tools for capturing infection dialogs in toto with visual and molecular precision.

Protein Science

John Pak’s Protein Science group develops and applies methods to design, produce, and characterize viral antigens and antibodies that are highly relevant to human health.

Quantitative Tissue Morphogenesis

Using a combination of zebrafish transgenesis, cutting-edge imaging tools, and mathematical modeling, Adrian Jacobo‘s group aims to understand how tissue architecture emerges from the spatial and temporal dynamics of cell–cell signaling.

Rapid Response Team

The Rapid Response Team, led by Cristina Tato, is collaborating with health agencies in the U.S. and in low- and middle-income countries to build capacity in sequencing, metagenomics, and molecular epidemiology.

Ribosomes and Human Disease

Ranen Aviner’s group uses molecular biology, transcriptomics, and proteomics to investigate how ribosomal networks change during viral infection or neurodegenerative disease, with the goal of designing rational therapeutic interventions.

Viral Replication and Transcription

Combining synthetic biology and genetic, biochemical, and computational approaches, Amy Kistler’s group aims to dissect and compare the minimal components, host-factor requirements, and function of diverse viral replication and transcription complexes.

Virus–Host Interactions

The group led by Carolina Arias explores virus–host interactions in cells infected with medically relevant viruses. Using comparative virology, the team aims to identify and validate conserved nodes within the proteostasis network that can be targeted pharmacologically to develop broad-spectrum antivirals.

Zebrahub

Zebrahub is a single-embryo, single-cell atlas of zebrafish vertebrate development.

OpenCell

OpenCell is a proteome-scale collection of protein localization and interaction measurements in human cells.

PoMeLo

A novel bioinformatic approach for identifying metabolic vulnerabilities of pathogens to inform host-directed therapeutics