An Age-Old Battle: Scientists Uncover What Makes Malaria Such a Wily Foe
A new study by researchers at CZ Biohub SF and UCSF points the way to a better vaccine design
Read stories from the life/science blog, news releases, and press coverage from Chan Zuckerberg Biohub San Francisco.
A new study by researchers at CZ Biohub SF and UCSF points the way to a better vaccine design
It will identify and locate every type of cell in the human body.
Program provides a critical entry point for medical doctors interested in scientific research
Metagenomic sequencing can be a cutting edge strategy to diagnose patients
A tool called metagenomic sequencing can help detect unknown pathogens, but widespread use faces challenges.
A technology that can screen for a wide range of disease-causing microbes in a single test could be a game-changer in diagnosing all kinds of infections. Joe DeRisi and other proponents of metagenomic sequencing say it is poised to...
A drug developed to quell urinary tract infections also appears to be a promising treatment for Balamuthia mandrillaris
OpenCell is a first-of-its-kind open-source website that’s mapping cells one protein at a time and paving a new way to visualize cellular architecture.
For CZ Biohub San Francisco research associate Rodrigo Baltazar-Nuñez, science is personal
CZ Biohub San Francisco partners with The 15 White Coats
From virtual staining to lensless microscopes, researchers are capitalizing on artificial intelligence to rethink microscopy
"Zebrahub" is an atlas of cells in developing zebrafish embryos, and scientists say it will help us learn about our own biology, too.
A ‘Google Earth’ of embryology, CZ Biohub San Francisco's zebrafish cell atlas brings a new vision to developmental biology
To alleviate the drudgery of sorting and picking transgenic zebrafish, CZ Biohub SF scientists and engineers developed this tool, thus accelerating the pace of research!
[NPR] “Think of it like collateral damage or friendly fire,” Joe DeRisi says.
[The New York Times] The sometimes fatal condition, MIS-C, may be driven in part by a misdirected immune system, a new study finds.
Study reveals a mechanism behind multisystem inflammatory syndrome in children (MIS-C)
Yasin Şenbabaoğlu, CZ Biohub SF’s new Director of Computational Biology, is working to reveal hidden patterns in health and disease
By lowering technical barriers, Omega democratizes image analysis
Comprehensive mapping of pathogen populations points way to precision treatments to improve outcomes
A rock-climbing scientist brings his exploratory spirit to science and medicine
From “bucket biochemist” to scientific leader, Sandra Schmid reflects on a life in the life sciences.
Brain-eating amoeba brings together researchers from CZ Biohub SF, UCSF, and the California Department of Public Health
Probing the sphinx tile to explore geometry and chirality in life
About 20 years ago, neuroscientists, recording from electrodes implanted in the medial temporal lobe, identified human brain cells that respond only to photos of Jennifer Aniston.
CZ Biohub San Francisco Investigator Hawa Racine Thiam’s new Stanford lab applies physics to the study of cells and their nuclei
Collaboration led by CZ Biohub SF Investigators unveils a new understanding of the sea star body plan
In the last couple decades, Malaysia has emerged as a global hotspot for neuroinfections such as encephalitis. Now a team from Universiti Malaya is collaborating with CZ Biohub SF to use metagenomics next-generation sequencing to help to...
CZ Biohub SF-backed NextGen initiative succeeds in diversifying faculty hiring in biological and biomedical sciences at major Bay Area universities
Did you know that zebrafish sense motion in the water using an organ very similar to the human cochlea? It’s called the lateral line and scientist Adrian Jacobo says studying it could help us restore function to human organs that have...
[Science Friday podcast] Guest host Flora Lichtman talks with Joe DeRisi about his fascinating work solving some of the most vexing medical mysteries, and how it may even help detect the next pandemic-inducing pathogen.
The San Francisco Biohub’s Computational Microscopy Platform, led by Shalin Mehta, has deployed a recently developed technology that lets standard microscopes acquire stunning high-resolution 3D images of cells without the need for...
[Mission Local] With all the talk of artificial intelligence swallowing the world, a group of San Francisco scientists have finally discovered a real-world application: Detecting malaria, a deadly disease that claims over half a million...
Three generations of scientists visit CZ Biohub SF to learn metagenomic sequencing techniques and analysis
In an extraordinarily effective collaboration, intercampus team creates highly detailed images of one the world’s most prevalent parasites
CZ Biohub San Francisco’s genomic epidemiology training empowered local health officials to respond to COVID and more
Analysis of nearly 300,000 people finds an association between the shingles jab and a lower rate of dementia — but questions linger.
Biohub-affiliated researchers are using the technology behind AI chatbots to unlock codes in human biology.
View the playlist from the Physics of Life Symposium.
CZ Biohub SF researchers and colleagues leverage genomics and machine learning to better diagnose LRTI, a major killer of children worldwide
A new study by researchers at CZ Biohub SF and UCSF points the way to a better vaccine design
It will identify and locate every type of cell in the human body.
Program provides a critical entry point for medical doctors interested in scientific research
Metagenomic sequencing can be a cutting edge strategy to diagnose patients
A tool called metagenomic sequencing can help detect unknown pathogens, but widespread use faces challenges.
A technology that can screen for a wide range of disease-causing microbes in a single test could be a game-changer in diagnosing all kinds of infections. Joe DeRisi and other proponents of metagenomic sequencing say it is poised to...
A drug developed to quell urinary tract infections also appears to be a promising treatment for Balamuthia mandrillaris
OpenCell is a first-of-its-kind open-source website that’s mapping cells one protein at a time and paving a new way to visualize cellular architecture.
Priscilla Chan and Mark Zuckerberg share their thoughts on five years of scientific progress at CZ Biohub.
How CZ Biohub deepened our understanding of disease, developed new technologies and therapies, and more, in our first five years.
A video from the Chan Zuckerberg Initiative.
A video from the Chan Zuckerberg Initiative.
Joe DeRisi on a new project with UCSF and Unidos en Salud to test for respiratory viruses, including using metagenomic sequencing if patients are negative for RSV, flu, and Covid.
Music, dance, cell culture – Leila Njoya does it all.
CZ Biohub’s Bioengineering team sends custom microscopes to Uganda to test out a new approach to diagnosing malaria
Building on CZ Biohub’s mission of bringing together leading researchers in the Bay Area, symposium will foster collaboration between fields
Kobayashi cited as among 'the brightest young minds' in research
Six Chan Zuckerberg Biohub Investigators are among the 2022 grantees of the High-Risk, High-Reward Program
The two San Francisco organizations signed an affiliation agreement to increase research collaboration
Sepsis diagnostic tool combines genomic sequencing with analysis of patients’ immune response for remarkable accuracy
‘CZ ID’ platform is helping researchers around the world identify new pathogens
New Group Leader brings a people-first approach to research
CZ Biohub works with Stanford’s Hopkins Marine Station to study sea creatures at the molecular and genomic level
CZ Biohub’s game-changing microscope seeks to inspire an international community of builders
It seems that Carolina Arias was destined to be a virologist. As a little girl growing up in Bogotá, she often accompanied her mother, a bacteriologist, to her clinical lab and watched her analyze samples from patients to figure out what...
American Society for Cell Biology honors Group Leader Manuel Leonetti for OpenCell project
CZ Biohub’s Physician-Scientist Fellowship helps bridge the gap between the clinic and the research lab
New work by CZ Biohub and Stanford scientists suggests that cells become senescent when they grow too large
Humans are good at looking at images and finding patterns or making comparisons. Look at a collection of dog photos, for example, and you can sort them by color, by ear size, by face shape, and so on. But could you compare them...
Chan Zuckerberg Biohub scientists develop a deep-learning method that reveals rich biological information on proteins and cell architecture
SAN FRANCISCO (July 11, 2022) – The Chan Zuckerberg Biohub (CZ Biohub) has named Mandana Asgharnejad as its new chief operating officer (COO), effective July 13, 2022. Mandana (who uses her first name professionally) joins CZ Biohub from...
New Group Leader brings an exploratory spirit to the Biohub
How climate change is increasing the risk of infectious disease
Massive project reveals gene-expression signatures in nearly half a million human cells, from 24 tissues and organs
The Chan Zuckerberg Biohub has named Melinda Griffith as its new chief legal officer (CLO)
CZ Biohub joins international effort to build the first cell atlas for a mainstay of biology
The Tabula Muris Consortium probes the mysteries of ‘young blood’ at the single-cell level
New tool can produce colorful high-resolution videos of developing organisms that are ‘marvelous to watch’
Scientists have made great strides in understanding the complexity of the cell in the nearly 360 years since English polymath Robert Hooke discovered this smallest unit of life. The anatomy of the cell and functions of its various internal...
For most of us, cutting out one or two unhealthy food items from our diet may be an efficient way to manage health, but the estimated 2 million people in the U.S. who live with celiac disease must permanently eliminate all foods containing...
Bioengineer will help lead Network’s efforts to observe, measure, and analyze human biology in action
We are delighted to announce the appointment of a stellar new group of Biohub Investigators who have been selected through nominations by our three partner universities—Stanford University, UC San Francisco, and UC Berkeley. All 10 of...
Fatherhood has had a major impact on Steve Quake’s scientific career. Years ago, when Quake and his wife were expecting their first child, a prenatal exam quickly took a startling turn. The doctor recommended amniocentesis to test the...
The development of molecular cell atlases has been crucially dependent on technological advances, which can be traced back three decades. Steve Quake revisits discoveries that transformed genetics.
Biohub-built ‘ZAF’ automates zebrafish care in the lab
A new study authored by Joe DeRisi provides reassurance that the BinaxNow test is performing as expected in catching Omicron infections.
Second cohort of CZ Biohub Investigators includes awardees from a broad range of disciplines, with fresh approaches to biological and medical problems
Biohub’s success inspires CZI to extend and expand support through 2031, replicate our model in new CZ Biohub Network
The image viewing and analysis software napari has filled a gap in the programming language’s scientific ecosystem.
‘Lab-on-a-chip’ platform enables a holistic approach to understanding how enzymes’ activity is optimized
A new survey from Unidos en Salud, which CZ Biohub is a part of, underscores importance of masks and testing along with vaccines.
Transformation of CZ Biohub’s summer internships aims to build more diverse teams, foster an inclusive environment in STEM careers
Sequencing all the RNA within individual mosquitoes can identify the potentially harmful viruses and emerging pathogens these insect vectors carry and transmit, as well as their animal reservoirs
Single-cell transcriptomics techniques enable one to abstract the cell as if it were a ‘bag of RNA’, enabling profound insight into the nature of cell state and cell identity.
CZ Biohub scientists are building an automated imaging system for low-resource settings to reliably detect malaria in blood samples
If you’re positive, you find out in minutes and can quarantine right away rather than waiting 48 hours or so for PCR test results.
Like Lewis Carroll’s Red Queen, cholera bacteria and their viral nemeses run a never-ending race just to keep up with each other
In his new book, Michael Lewis profiles people who tried to sound the alarm about COVID-19 as officials failed to act – including CZ Biohub Co-President Dr. Joe DeRisi.
Even if you’re vaccinated, you could be spreading COVD-19 to others if you’re infected — that’s why the CDC is now encouraging indoor mask wearing.
The people hunting for mutations want the country to fix its virus sequencing mess.
Carl Zimmer of the New York Times and CZ Biohub Co-President Joe DeRisi discussed the impact of COVID-19 on science and public health
An engineering physicist reflects on his role in CZ Biohub’s response to the COVID-19 pandemic
Unique study combines cryoEM, AI to forge atomic-level model of Nsp2
The organization of cells into discrete compartments such as cilia and endosomes allows for localized decision-making.
A virtual collaboration overcame supply-chain constraints to quickly develop a versatile, low-cost ventilator for COVID-19 patients.
Joe DeRisi invented a way to find pathogens that scientists didn’t even know to look for. Can it help prevent the next pandemic?
Researchers have found a way to double doctors’ accuracy in detecting the vast majority of complex fetal heart defects in utero by combining routine ultrasound imaging with machine-learning computer tools.
A Biohub project, Tabula Sapiens, aims to create an atlas of single-cell gene expression that will allow scientists to control for factors like genetic inheritance, age, epigenetics, and environment.
He’d just been reading the news, like everyone else. He had no special access to any new disease outbreak, and no one would have expected him to intervene. All that Joe DeRisi had was his new lab at the University of California, San...
The pandemic has hit Latino families harder than any other ethnic group in the Bay Area, and now an all-star team of researchers and community organizers backed by funds from the Chan Zuckerberg Initiative is working to change that
Engineers at the University of California, Berkeley, have created a tiny wireless implant that can provide real-time measurements of tissue oxygen levels deep underneath the skin. The device, which is smaller than the average ladybug and...
Draft scientific manuscripts are typically confidential. So, when Elana Fertig was asked to take a look at an in-development paper on a functional gene-annotation strategy, she expected to receive the file in a private e-mail. What she got...
A variant first discovered in California in December is more contagious than earlier forms of the coronavirus, two new studies have shown, fueling concerns that emerging mutants like this one could hamper the sharp decline in cases over...
On January 25, a man vacationing in Cambodia with his family went swimming in their hotel pool. After toweling off, he spiked a fever and was sent to a local hospital, where his nose and throat were swabbed and the samples were tested for a...
A major mystery in Alzheimer’s disease research is why some brain cells succumb to the creeping pathology of the disease years before symptoms first appear, while others seem impervious to the degeneration surrounding them until the...
The Chan Zuckerberg Biohub has selected eleven early-career physicians at Stanford University and the University of California, San Francisco, to pursue their interests in biomedical research through the newly launched CZ Biohub...
A global pandemic is something Joe DeRisi has been preparing for his entire career. What he didn’t expect was that the viral scourge would ravage so close to home. DeRisi was in the process of standing up sequencing technology to help...
To live in San Francisco for the past 20 years has been to live with outrage that a society so innovative and compassionate can so reliably fail to meet even the most basic challenges of public life. This city never stopped being...
No one who passed the young woman on the street that night gave her so much as a second glance. It was a Saturday evening in the South Beach neighborhood of San Francisco and she was heading away from the stadium where the San Francisco...
UCSF to expand COVID-19 clinical laboratory facilities with the collaboration of the Chan Zuckerberg Biohub
Word got out here that nasal swabs were the only thing standing between Northern California and a lot of coronavirus testing, and people with a talent for figuring out things began to figure things out. Marc Benioff, the chief executive of...
A decade ago Joe DeRisi received a letter from a woman with a picture of herself wrapped in a boa constrictor. “I heard you’re a virus hunter,” the letter began before going on to explain that the snake, which she referred to as...
FOR IMMEDIATE RELEASE SAN FRANCISCO — The Chan Zuckerberg Biohub, a nonprofit medical research organization, has launched the CZ Biohub Physician-Scientist Fellowship Program designed to train the next generation of physician-scientists...
FOR IMMEDIATE RELEASE SAN FRANCISCO — May 6, 2019 — The Chan Zuckerberg Biohub (CZ Biohub), an innovative nonprofit medical research organization, has hired renowned health-tech veteran Sonya Zilka as vice president of human resources....
New open-source, cloud-based tool rapidly interprets terabytes of data to detect disease-causing pathogens In an ongoing pilot project and partnership with the Bill & Melinda Gates Foundation, IDseq is helping to identify mystery...
New funding from CZ Biohub fosters further scientific research collaboration between Stanford; University of California, Berkeley; and University of California, San Francisco CZ Biohub Microbiome Initiative and Intercampus Research Awards...
FOR IMMEDIATE RELEASE SAN FRANCISCO — Sept. 17, 2018 — The Chan Zuckerberg Biohub (CZ Biohub), a nonprofit medical research organization, has hired prominent litigation attorney and law firm leader Maureen Sheehy as general counsel....
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